microscope medical research
microscope medical research

Reyad Abbadi

I studied Medicine at King’s College London and qualified with an MB, BS in 1995. Most of my post-graduate clinical training took place at King’s College Hospital, one of Europe’s foremost centres for the treatment of liver disease. In addition to training in Hepatobiliary and Pancreatic Surgery, I also received training in all aspect of General Surgery.

During my training I took up an academic appointment with King’s College London as a Lecturer in Surgery. I undertook clinical and basic science research as well as teaching.

At the end of my training, I undertook a fellowship at Addenbrooke’s Hospital in Cambridge in Hepatobiliary and Pancreatic Surgery. Cambridge is a renowned centre for transplant surgery and it was here that I also undertook a two-year training fellowship in solid organ transplantation (liver, pancreas, kidney and multi-visceral).

I obtained my Certificate of Completion of Specialist Training in 2008 and I am on the Specialist Register of the General Medical Council.

My clinical practice is in open, laparoscopic and robotic surgery of the gallbladder and bile ducts, liver, pancreas and general surgery. I also have an interest in abdominal sarcomas and complex abdominal tumours. I treat both benign and malignant conditions.

I am married to an academic and have one daughter and two sons. My family occupies most of any free time that I have.

Research

  • Managing and repairing complications of gallbladder surgery
  • Laparoscopic and robotic surgery
  • Diagnostic modalities of colorectal liver metastases
  • Epigenetics in carcinogenesis of gastrointestinal malignancies

I have published on the treatment of several surgical conditions within the spheres of general and hepatobiliary surgery. I have an active research interest in the management of complications of gallbladder surgery, diagnostic modalities of metastatic tumours to the liver, cystic tumours of the pancreas and laparoscopic and robotic surgery. I pioneered trans-thoracic minimal access surgery in the UK. This allows removal of liver tumours which are difficult to access other than by open surgery.

My Doctorate in Medicine (MD) thesis, which was obtained from the University of London in 2008, was on how epigenetic changes (the study of the influence of environmental factors on the genetic code) lead to the development of cancer.

Publications

Books and book chapters

  • MCQs and EMQs for the MRCS. R Al-Ghnaniem & IS Benjamin. BIOS Scientific Publishers Limited. Oxford 1999.
  • Benign and Malignant Lesions of the Biliary Tract. R Al-Ghnaniem & IS Benjamin in Companion in Surgical Practice: Hepatobiliary and Pancreatic Surgery. OJ Garden (Ed.). Harcourt Brace, London 2001.
  • Obstructive Jaundice. R Al-Ghnaniem & IS Benjamin in Case Presentations for the MRCS and AFRCS. Hornick, Grace and Lumley (Eds). Butterworth Heinemann, 1997.

Papers

  • Baos S, Lui M, Walker-Smith T, Pufulete M, Messenger D, Abbadi R, et al. Gabapentin for Pain Management after Major Surgery: A Placebo-controlled, Double-blinded, Randomized Clinical Trial (the GAP Study). Anesthesiology. 2025;143:851-861.
  • Wong NACS, Abdalkoddus M, Al-Khafaji N, Roach H, Abbadi R. Simple biliary cysts of the liver can be lined by mucinous epithelium. Histopathology. 2022;81:402-406.
  • Pathak S, Main BG, Blencowe NS, Rees JRE, Robertson HF, Abbadi RAG, Blazeby JM. A Systematic Review of Minimally Invasive Trans-thoracic Liver Resection to Examine Intervention Description, Governance, and Outcome Reporting of an Innovative Technique. Ann Surg. 2021;273:882-889.
  • Baos S, Rogers CA, Abbadi R, Alzetani A, Casali G, Chauhan N, et al. Effectiveness, cost-effectiveness and safety of gabapentin versus placebo as an adjunct to multimodal pain regimens in surgical patients: protocol of a placebo controlled randomised controlled trial with blinding (GAP study). BMJ Open. 2020;10:e041176.
  • Lee KS, Suchett-Kaye I, Abbadi R, Finch-Jones M, Pope I, Strickland A, Rees J. Microscopic resection margins adversely influence survival rates after surgery for colorectal liver metastases: An open ambidirectional Cohort Study. Int J Surg. 2020;83:8-14.
  • Bureau C, Adebayo D, de Rieu MC, Elkrief L, Valla D, Peck-Radosavljevic M, et al. Corrigendum to ‘Alfapump system vs. large volume paracentesis for refractory ascites: A multicenter randomized controlled study’ [J Hepatol 67 (2017) 940-949]. J Hepatol. 2018;68:630.
  • Balakrishnan A, Abbadi R, Oakland K, Jamdar S, Harper SJ, Jamieson NV, et al. Outcomes following liver trauma in equestrian accidents. J Trauma Manag Outcomes. 2014;8:13.
  • Abbadi RA, Sadat U, Jah A, Praseedom RK, Jamieson NV, Cheow HK, et al. Improved long-term survival after resection of colorectal liver metastases following staging with FDG positron emission tomography. J Surg Oncol. 2014;110:313-9.
  • Pufulete M, Al-Ghnaniem Abbadi R, Arno M, Ewins M, Green C, Aldecoa-Otalora Astarloa E, Sanders T, Emery P. The influence of folate supplementation on global gene expression in normal colonic mucosa of subjects with colorectal adenoma. Mol Nutr Food Res. 2013;57:709-20.
  • Al-Ghnaneim Abbadi R, Emery P, Pufulete M. Short-term folate supplementation in physiological doses has no effect on ESR1 and MLH1 methylation in colonic mucosa of individuals with adenoma. J Nutrigenet Nutrigenomics (in press).
  • Ausania F, Al-Ghnaniem R, Jamieson NV, Praseedom RK. Clinical impact of right accessory hepatic artery injury in deceased donor livers. J Hepatobiliary Pancreat Sci. 2012;19:656-60
  • Ausania F, Al-Ghnaniem R, Jamieson NV, Praseedom RK. Potential and actual liver donors: is the difference predictable? Transplantation. 2011;91:e20-1
  • Al-Ghnaniem R, Ahmed I, Bosanac Z, Philips S. Successful laparoscopic repair of acute intrapericardial diaphragmatic hernia secondary to penetrating trauma. J Trauma. 2009;67:E181-2.
  • Ally M, Al-Ghnaniem R, Pufulete M. The relationship between gene-specific DNA methylation in leukocytes and normal colorectal mucosa in subjects with and without colorectal tumors. Cancer Epidemiol Biomarkers Prev. 2009;18:922-8.
  • Al-Ghnaniem R, Camprodon RAM, Kocher HM et al. Strategy to reduce the risk of positive pancreatic resection margin at pancreatico-duodenectomy. ANZ J Surg. 2008;78:237-9
  • Al-Ghnaniem R, Peters J, Foresti R et al. Methylation of ER and MLH1 in normal colonic mucosa: association with folate/vitamin B12 status in subjects with and without colorectal neoplasia. Am J Clin Nutr. 2007;86:1064-72

Papers Cont.

  • Al-Ghnaniem R, Short K, Pullen A et al. 1% Hydrocortisone ointment is an effective treatment of pruritus ani: a pilot randomised controlled crossover trial. Int J Colorectal Dis. 2007;22:1463-7
  • Camprodon R A M, Jacob S, Malkawi A, Al-Ghnaniem R. CMV colitis presenting as acute abdomen requires early diagnosis and treatment to avoid mortality. Acta Chir Belg. 2007;107:378-81
  • Kocher H, Warwick J, Al-Ghnaniem R et al. Surgical dexterity after a ‘night out on the town’. ANZ J Surg. 2006;76:110-2
  • Pufulete M, Al-Ghnaniem R, Rennie JA et al. The influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer. Br J Cancer. 2005;92:838-42
  • Pufulete M, Al-Ghnaniem R, Khushal A et al. Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma. Gut. 2005;54:648-53
  • Camprodon RA, Al-Ghnaniem R, Camprodon R, Transgastric surgery for posterior juxta-cardial ulcers: a minimal and safe approach. Arch Surg. 2003;138:757-61
  • Pufulete M, Al-Ghnaniem R, Leather AJM et al. Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. Gastroenterology. 2003;124:1240-8
  • Al-Ghnaniem R, Benjamin IS, Patel AG. Meta-analysis suggests antibiotic prophylaxis is not warranted in low-risk patients undergoing laparoscopic cholecystectomy. Br J Surg. 2003;90:365-366
  • Al-Ghnaniem R, Benjamin IS. Long-term outcome of hepatico-jejunostomy with routine access loop formation following bile duct injury at cholecystectomy. Br J Surg.2002;89:1118-24
  • Al-Ghnaniem R, Kocher HM, Patel AG. Predicting inflammation of the appendix at open and laparoscopic appendicectomy: findings and consequences. Eur J Surg. 2002;168(1):4-7
  • Al-Ghnaniem R, Leather AJM, Rennie JA. A survey of current treatment of haemorrhoids and complication of injection sclerotherapy. Annals Roy Coll Surg Engl 2001; 83:3